Evidence for copper homeostasis function of metallothionein (MT3) in the hyperaccumulator Thlaspi caerulescens.

@article{Roosens2004EvidenceFC,
  title={Evidence for copper homeostasis function of metallothionein (MT3) in the hyperaccumulator Thlaspi caerulescens.},
  author={Nancy H. C. Roosens and Catherine Bernard and Raphael Leplae and Nathalie Verbruggen},
  journal={FEBS letters},
  year={2004},
  volume={577 1-2},
  pages={9-16}
}
Metallothioneins chelate metals and consequently may be a control point of metal homeostasis. Homologous to type 3 metallothioneins, TcMT3 cDNA was identified in the Cd/Zn hyperaccumulator, Thlaspi caerulescens. TcMT3 amino acid sequence showed modifications in the Cys positions when compared with its Arabidopsis orthologue. A structural model established that the MT3 carboxyterminal domain is similar to the beta domain of animal metallothioneins and predicts a smaller cavity to chelate metals… CONTINUE READING

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