Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs

@inproceedings{Marques2012EvidenceFC,
  title={Evidence for conserved post-transcriptional roles of unitary pseudogenes and for frequent bifunctionality of mRNAs},
  author={Ana Claudia Marques and Jennifer Yihong Tan and Sheena R Lee and Lesheng Kong and Andreas Heger and Chris Paul Ponting},
  booktitle={Genome Biology},
  year={2012}
}
Recent reports have highlighted instances of mRNAs that, in addition to coding for protein, regulate the abundance of related transcripts by altering microRNA availability. These two mRNA roles - one mediated by RNA and the other by protein - are inter-dependent and hence cannot easily be separated. Whether the RNA-mediated role of transcripts is important, per se, or whether it is a relatively innocuous consequence of competition by different transcripts for microRNA binding remains unknown… CONTINUE READING
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