Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex

@article{Devoto2001EvidenceFC,
  title={Evidence for co-release of noradrenaline and dopamine from noradrenergic neurons in the cerebral cortex},
  author={Paola Devoto and Giovanna Flore and L. Pani and Gian Luigi Gessa},
  journal={Molecular Psychiatry},
  year={2001},
  volume={6},
  pages={657-664}
}
The aim of this study was to determine whether extracellular dopamine (DA) in the prefrontal cortex (PFC) might originate other than from DA neurons, also from noradrenergic (NA) ones. To this aim, we compared the levels of DA and NA in the dialysates from the PFC, a cortical area innervated by NA and DA neurons, and cortices that receive NA but minor or no DA projections such as the primary motor, the occipital-retrosplenial, and the cerebellar cortex. Moreover, the effect of α2-ligands and D2… CONTINUE READING

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