Evidence for chemoreceptors with bimodular ligand-binding regions harboring two signal-binding sites.

@article{PinedaMolina2012EvidenceFC,
  title={Evidence for chemoreceptors with bimodular ligand-binding regions harboring two signal-binding sites.},
  author={Estela Pineda-Molina and Jos{\'e}-Antonio Reyes-Dar{\'i}as and Jes{\'u}s Lacal and Juan L. Ramos and Juan Manuel Garc{\'i}a-Ruiz and Jos{\'e} A Gavira and Tino Krell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 46},
  pages={
          18926-31
        }
}
Chemoreceptor-based signaling is a central mechanism in bacterial signal transduction. Receptors are classified according to the size of their ligand-binding region. The well-studied cluster I proteins have a 100- to 150-residue ligand-binding region that contains a single site for chemoattractant recognition. Cluster II receptors, which contain a 220- to 300-residue ligand-binding region and which are almost as abundant as cluster I receptors, remain largely uncharacterized. Here, we report… CONTINUE READING
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