Evidence for changes in beta- and gamma-actin proportions during inner ear hair cell life.

@article{Andrade2015EvidenceFC,
  title={Evidence for changes in beta- and gamma-actin proportions during inner ear hair cell life.},
  author={Leonardo Andrade},
  journal={Cytoskeleton},
  year={2015},
  volume={72 6},
  pages={282-91}
}
Cytoplasmic actin isoforms beta (β-) and gamma (γ-) perform crucial physiological roles in inner ear hair cells (HC). The stereocilium, which is structured by parallel actin filaments composed of both isoforms, is the responsive organelle to mechanical stimuli such as sound, gravity and head movements. Modifications in isoform proportions affect the function of the stereocilia as previously shown in genetic studies of mutant mice. Here, immunogold labeling TEM studies in mice showed that both… CONTINUE READING
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