Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve

@article{Mor2011EvidenceFC,
  title={Evidence for cellular injury in the midbrain of rats following chronic constriction injury of the sciatic nerve},
  author={David Mor and Alison L. Bembrick and Paul J Austin and Kevin A Keay},
  journal={Journal of Chemical Neuroanatomy},
  year={2011},
  volume={41},
  pages={158-169}
}
Complex behavioural disabilities, as well as pain, characterise neuropathic pain conditions for which clinical treatment is sought. In rats, chronic constriction injury (CCI) of the sciatic nerve evokes, allodynia and hyperalgesia as well as three distinct patterns of disability, characterised by changes in social and sleep-wake behaviours: (i) Pain & Disability; (ii) Pain & Transient Disability and (iii) Pain alone. Importantly, the degree of allodynia and hyperalgesia is identical for each of… CONTINUE READING
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