Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension.

@article{Majka2008EvidenceFC,
  title={Evidence for cell fusion is absent in vascular lesions associated with pulmonary arterial hypertension.},
  author={Susan M. Majka and Margaret C. Skokan and Lisa R. Wheeler and Julie Harral and Santhi Gladson and Ellen L Burnham and James E Loyd and Kurt R Stenmark and Marileila Varella-Garcia and James West},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2008},
  volume={295 6},
  pages={L1028-39}
}
Pulmonary arterial hypertension (PAH) is a fatal disease associated with severe remodeling of the large and small pulmonary arteries. Increased accumulation of inflammatory cells and apoptosis-resistant cells are contributing factors. Proliferative apoptosis-resistant cells expressing CD133 are increased in the circulation of PAH patients. Circulating cells can contribute to tissue repair via cell fusion and heterokaryon formation. We therefore hypothesized that in the presence of increased… CONTINUE READING

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