Evidence for camel-to-human transmission of MERS coronavirus.
@article{Azhar2014EvidenceFC, title={Evidence for camel-to-human transmission of MERS coronavirus.}, author={Esam Ibraheem Azhar and Sherif Aly El-Kafrawy and Suha Abdulall Farraj and Ahmed Mohamed Hassan and Muneera S Al-Saeed and Anwar M. Hashem and Tariq A. Madani}, journal={The New England journal of medicine}, year={2014}, volume={370 26}, pages={ 2499-505 } }
We describe the isolation and sequencing of Middle East respiratory syndrome coronavirus (MERS-CoV) obtained from a dromedary camel and from a patient who died of laboratory-confirmed MERS-CoV infection after close contact with camels that had rhinorrhea. Nasal swabs collected from the patient and from one of his nine camels were positive for MERS-CoV RNA. In addition, MERS-CoV was isolated from the patient and the camel. The full genome sequences of the two isolates were identical. Serologic…Â
386 Citations
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High seroprevalence of Middle East respiratory syndrome corona virus (MERS-CoV) in dromedary camels has been previously reported in United Arab Emirates (UAE). However, the molecular detection of the…
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All published data on MERS-coronavirus (CoV) in the global camel population is compiled and analysed to provide an overview of current knowledge on the distribution, spread and risk factors of infections in dromedary camels.
References
SHOWING 1-10 OF 17 REFERENCES
Middle East respiratory syndrome coronavirus in dromedary camels: an outbreak investigation
- Biology, MedicineThe Lancet Infectious Diseases
- 2014
Family cluster of Middle East respiratory syndrome coronavirus infections.
- MedicineThe New England journal of medicine
- 2013
A family case cluster of Mers-CoV infection is described, including the clinical presentation, treatment outcomes, and household relationships of three young men who became ill with MERS- coV infection after the hospitalization of an elderly male relative, who died of the disease.
Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study
- Biology, MedicineThe Lancet Infectious Diseases
- 2013
Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia.
- Medicine, BiologyThe New England journal of medicine
- 2012
The clinical picture was remarkably similar to that of the severe acute respiratory syndrome (SARS) outbreak in 2003 and reminds us that animal coronaviruses can cause severe disease in humans.
Transmission and evolution of the Middle East respiratory syndrome coronavirus in Saudi Arabia: a descriptive genomic study
- Biology, MedicineThe Lancet
- 2013
Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
- BiologyEmerging infectious diseases
- 2013
The identification of a South Africa bat derived CoV that has an even closer phylogenetic relationship with MERS-CoV is reported, and is as close as that of SARS- coV and the most closely related bat coronavirus known.
Clinical features and viral diagnosis of two cases of infection with Middle East Respiratory Syndrome coronavirus: a report of nosocomial transmission
- Medicine, BiologyThe Lancet
- 2013
Hospital outbreak of Middle East respiratory syndrome coronavirus.
- MedicineThe New England journal of medicine
- 2013
Person-to-person transmission of MERS-CoV can occur in health care settings and may be associated with considerable morbidity and surveillance and infection-control measures are critical to a global public health response.
Seroepidemiology for MERS coronavirus using microneutralisation and pseudoparticle virus neutralisation assays reveal a high prevalence of antibody in dromedary camels in Egypt, June 2013.
- BiologyEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- 2013
The newly developed ppNT assay does not require Biosafety Level 3 containment and is thus a relatively high-throughput assay, well suited for large-scale seroepidemiology studies which are needed to better understand the ecology and epidemiology of MERS-CoV.
Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012.
- Medicine, BiologyEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin
- 2012
The clinical and virological features of a novel coronavirus infection causing severe respiratory illness in a patient transferred to London, United Kingdom, from the Gulf region of the Middle East are described.