Evidence for calcitonin receptor heterogeneity: binding studies with nonhelical analogs.

@article{Nakamuta1990EvidenceFC,
  title={Evidence for calcitonin receptor heterogeneity: binding studies with nonhelical analogs.},
  author={Hiromichi Nakamuta and Ronald C. Orlowski and Richard M Epand},
  journal={Endocrinology},
  year={1990},
  volume={127 1},
  pages={163-9}
}
Binding of the nonhelical salmon calcitonin (sCT) analog, [Gly8,Ala16]-des-Leu19-sCT to membrane preparations from rat brain could be analyzed in terms of two independent binding sites. The high and low affinity binding sites for this analog were named CT-L (L, linear) and CT-H (H, helix), respectively. Although the CT-H type receptor has a low affinity for the nonhelical analogs, it binds the helical sCT with high affinity and therefore represents a CT binding site. The physiological… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.

Similar Papers

Loading similar papers…