Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology

@article{Abbott2004EvidenceFB,
  title={Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology},
  author={N. Joan Abbott},
  journal={Neurochemistry International},
  year={2004},
  volume={45},
  pages={545-552}
}
  • N. Abbott
  • Published 1 September 2004
  • Medicine, Biology
  • Neurochemistry International
This review surveys evidence for the flow of brain interstitial fluid (ISF) via preferential pathways through the brain, and its relation to cerebrospinal fluid (CSF). Studies over >100 years have raised several controversial points, not all of them resolved. Recent studies have usefully combined a histological and a mathematical approach. Taken together the evidence indicates an ISF bulk flow rate of 0.1-0.3 microl min(-1) g(-1) in rat brain along preferential pathways especially perivascular… 
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