Evidence for breast cancer as an integral part of Lynch syndrome.

  title={Evidence for breast cancer as an integral part of Lynch syndrome.},
  author={Nicole Buerki and Lucienne Gautier and Michal B. Kovac and Giancarlo Marra and Mauro Buser and Hansjakob Mueller and Karl Heinimann},
  journal={Genes, chromosomes & cancer},
  volume={51 1},
Lynch syndrome, an autosomal dominant cancer predisposition caused by mutations in DNA mismatch repair (MMR) genes, mainly mainly mutL homolog 1, OMIM 120436 (MLH1) and mutS homolog 2, OMIM 609309 (MSH2), encompasses a tumor spectrum including primarily gastrointestinal, endometrial, and ovarian cancer. This study aimed at clarifying the heavily debated issue of breast cancer being part of Lynch syndrome. Detailed clinical data on cancer occurrence in Swiss female MLH1/MSH2 mutation carriers… CONTINUE READING
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