Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin

@article{Blokhuis2009EvidenceFB,
  title={Evidence for balancing selection acting on KIR2DL4 genotypes in rhesus macaques of Indian origin},
  author={Jeroen H Blokhuis and Marit K. H. van der Wiel and Gaby G. M. Doxiadis and Ronald Bontrop},
  journal={Immunogenetics},
  year={2009},
  volume={61},
  pages={503-512}
}
The interaction of killer-cell immunoglobulin-like receptors (KIR) and their respective major histocompatibility complex (MHC) ligands can alter the activation state of the natural killer (NK) cell. In both humans and rhesus macaques, particular types of non-classical MHC class I molecules are predominantly expressed on the trophoblast. In humans, human leukocyte antigen G has been demonstrated to act as a ligand for KIR2DL4, present on all NK cells, whereas Mamu-AG may execute a similar… CONTINUE READING
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Comparative genetics of a highly divergent DRB microsatellite in different macaque species

  • N deGroot, GG Doxiadis, AJ deVos-Rouweler, NG Groot, EJ Verschoor, RE Bontrop
  • Immunogenetics
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