Evidence for autoregulation of cystathionine gamma-synthase mRNA stability in Arabidopsis.

@article{Chiba1999EvidenceFA,
  title={Evidence for autoregulation of cystathionine gamma-synthase mRNA stability in Arabidopsis.},
  author={Yukako Chiba and Mari Ishikawa and Fumiko Kijima and Rebecca Tyson and Jaebum Kim and Ayumu Yamamoto and Eiji Nambara and Thomas Leustek and Roger M. Wallsgrove and Satoshi Naito},
  journal={Science},
  year={1999},
  volume={286 5443},
  pages={1371-4}
}
Control of messenger RNA (mRNA) stability serves as an important mechanism for regulating gene expression. Analysis of Arabidopsis mutants that overaccumulate soluble methionine (Met) revealed that the gene for cystathionine gamma-synthase (CGS), the key enzyme in Met biosynthesis, is regulated at the level of mRNA stability. Transfection experiments with wild-type and mutant forms of the CGS gene suggest that an amino acid sequence encoded by the first exon of CGS acts in cis to destabilize… CONTINUE READING
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