Evidence for autophagic gridlock in aging and neurodegeneration.

  title={Evidence for autophagic gridlock in aging and neurodegeneration.},
  author={Mathieu F Bakhoum and Christine Y Bakhoum and Zhixia Ding and Susan M. Carlton and Gerald A. Campbell and George R. Jackson},
  journal={Translational research : the journal of laboratory and clinical medicine},
  volume={164 1},
Autophagy is essential to neuronal homeostasis, and its impairment is implicated in the development of neurodegenerative pathology. However, the underlying mechanisms and consequences of this phenomenon remain a matter of conjecture. We show that misexpression of human tau in Drosophila induces accumulation of autophagic intermediates with a preponderance of large vacuoles, which we term giant autophagic bodies (GABs), which are reminiscent of dysfunctional autophagic entities. Lowering basal… CONTINUE READING
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