Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.

@article{Siegfried1999EvidenceFA,
  title={Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.},
  author={Jill M. Siegfried and N Krishnamachary and A Gaither Davis and Christopher T. Gubish and Jay D. Hunt and Sharon P. Shriver},
  journal={Pulmonary pharmacology & therapeutics},
  year={1999},
  volume={12 5},
  pages={291-302}
}
Gastrin-releasing peptide (GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion. In this report, we demonstrate that both GRP and another member of the bombesin family of peptides, neuromedin B (NMB), are also autocrine growth factors for non-small cell lung carcinoma (NSCLC). Using the reverse transcription-polymerase chain reaction (RT-PCR), we have detected mRNA for… CONTINUE READING