Evidence for atrophy of the corpus callosum in Alzheimer's disease.

  title={Evidence for atrophy of the corpus callosum in Alzheimer's disease.},
  author={Patrick Vermersch and Phillip Scheltens and Frederik Barkhof and Marc Steinling and Didier Leys},
  journal={European neurology},
  volume={34 2},
Patients with late-onset Alzheimer's disease (AD) have more white matter changes on magnetic resonance imaging (MRI) than controls. To test the hypothesis that AD patients might have also atrophy of the corpus callosum (CC), we compared the CC thickness on MRI from 20 AD patients and 21 controls. We found a significant reduction in the CC thickness in AD compared with age-matched controls (p < 0.01). We demonstrated that atrophy of the CC depends mainly on the diagnosis of senile dementia of… CONTINUE READING

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