Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIα gene (PIP5K2A) with schizophrenia

@article{Schwab2006EvidenceFA,
  title={Evidence for association of DNA sequence variants in the phosphatidylinositol-4-phosphate 5-kinase IIα gene (PIP5K2A) with schizophrenia},
  author={Sibylle G. Schwab and Michael Knapp and Pamela Sklar and Gertrud N Eckstein and C Sewekow and Margitta Borrmann-Hassenbach and Margot Albus and Tim Becker and Joachim F. Hallmayer and Bernard Lerer and Wolfgang Maier and Dieter D B Wildenauer},
  journal={Molecular Psychiatry},
  year={2006},
  volume={11},
  pages={837-846}
}
Linkage studies in schizophrenia have identified a candidate region on chromosome 10p14–11 as reported for several independent samples. We investigated association of DNA sequence variants in a plausible candidate gene located in this region, the gene for phosphatidylinositol-4-phosphate 5-kinase IIα (PIP5K2A), in a sample of 65 sib-pair families for which linkage had been reported. Evidence for association was obtained for 15 polymorphisms spanning 73.6 kb in the genomic region of the gene… CONTINUE READING
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