Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.

@article{Awata1997EvidenceFA,
  title={Evidence for association between the class I subset of the insulin gene minisatellite (IDDM2 locus) and IDDM in the Japanese population.},
  author={Takuya Awata and Susumu Kurihara and Chika Kikuchi and Shin Takei and Ikuo Inoue and Chieko Ishii and Kazuhisa Takahashi and Kosuke Negishi and Yoshihiro Yoshida and Ryoko Hagura and Yasuhiko Kanazawa and Shigehiro Katayama},
  journal={Diabetes},
  year={1997},
  volume={46 10},
  pages={1637-42}
}
Although the shortest (class I) minisatellite (i.e., variable number of tandem repeats [VNTR]) alleles in the 5' region of the insulin gene are positively associated with IDDM in Caucasians, the majority of Japanese are homozygous for class I alleles. Here, we determined the exact length, in number of repeat units (RUs), of class I alleles in Japanese subjects. The distribution of class I alleles in Japanese was trimodal, with peaks located at 32/33, 41, and 44 RUs. The shortest component (i.e… CONTINUE READING
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