Evidence for arsenic essentiality
@article{Uthus1992EvidenceFA,
title={Evidence for arsenic essentiality},
author={Eric O. Uthus},
journal={Environmental Geochemistry and Health},
year={1992},
volume={14},
pages={55-58}
}Although numerous studies with rats, hamsters, minipigs, goats and chicks have indicated that arsenic is an essential nutrient, the physiological role of arsenic is open to conjecture. Recent studies have suggested that arsenic has a physiological role that affects the formation of various metabolites of methionine metabolism including taurine and the polyamines. The concentration of plasma taurine is decreased in arsenic-deprived rats and hamsters. The hepatic concentration of polyamines and…
86 Citations
Arsenic essentiality: A role affecting methionine metabolism
- Biology
- 2003
Results show that compared to controlled amounts, having too little or too much arsenic in the diet is harmful; however, there is an amount of dietary arsenic that is not only not harmful, but beneficial.
The Importance of Arsenic , Vanadium , Cobalt and
- 2017
The modern poultry production experienced a huge development in recent decades. In the middle of 2000 s, the body weight of a commercial broiler chicken reached 2 kg in 5 weeks, down from 9 weeks in…
Diethyl maleate, an in vivo chemical depletor of glutathione, affects the response of male and female rats to arsenic deprivation
- Biology, PsychologyBiological Trace Element Research
- 2007
Compared to males, females had extremely elevated kidney calcium concentrations, and that the elevation was exacerbated by arsenic deprivation, which may be explained by the differences in methionine metabolism between male and female rats.
Enzymatic methylation of arsenic species and other new approaches to arsenic toxicity.
- BiologyAnnual review of pharmacology and toxicology
- 1997
A hypothesis that the lack of arsenite methyltransferases may have had an evolutionary advantage for certain species is proposed.
Developmental and reproductive toxicity of inorganic arsenic: animal studies and human concerns.
- BiologyJournal of toxicology and environmental health. Part B, Critical reviews
- 1998
Animal studies suggest that environmental arsenic exposures are primarily a risk to the developing fetus, and attention must be given to comparative pharmacokinetics and metabolism, likely exposure scenarios, possible mechanisms of action, and the potential role of arsenic as an essential nutrient.
Arsenic. Can this toxic metalloid sustain life?
- BiologyMetal ions in life sciences
- 2013
Evidence is examined that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed and its Janus-faced ability to effectively treat APL is considered.
Arsenicosis: review of recent advances.
- MedicineThe Journal of the Association of Physicians of India
- 2010
Human exposure to arsenic in non occupational population, mostly through drinking water which is a worldwide problem, more so in south East Asia is reviewed, and experimental and epidemiological evidence support diabetes effect of high level arsenic exposure.
The Minimal Arsenic Concentration Required to Inhibit the Activity of Thyroid Peroxidase Activity In Vitro
- Biology, MedicineBiological Trace Element Research
- 2008
A significant dose–response relationship with the highest concentration of arsenic producing the greatest amount of TPO inhibition is indicated, and the minimal dose required to inhibit this activity is between 0.1 and 1 ppm.
Dietary arsenic affects dimethylhydrazine-induced aberrant crypt formation and hepatic global DNA methylation and DNA methyltransferase activity in rats
- BiologyBiological Trace Element Research
- 2007
There is a threshold for As toxicity and that possibly too little dietary As could also be detrimental, and an increased number of aberrant Crypts and aberrant crypt foci, DNA hypomethylation, and increased DNMT tended to hold when comparing rats fed the diet containing no supplemental arsenic compared to rats fed 0.5 μg As/g.
Importance of making dietary recommendations for elements designated as nutritionally beneficial, pharmacologically beneficial, or conditioinally essential
- Medicine
- 2000
Findings have been described to suggest that these six elements have effects at physiological or pharmacological amounts that can promote health and reduce risks leading to disease, and therefore they may be soon generally accepted as established essential elements.
References
SHOWING 1-7 OF 7 REFERENCES
Effect of dietary pyridoxine on arsenic deprivation in rats.
- BiologyMagnesium and trace elements
- 1991
It is demonstrated that dietary pyridoxine and arsenic interact and that the methionine status of the animal can affect this interaction, as well as other parameters including blood indices, erythrocyte aspartate aminotransferase and the concentration of tissue iron and plasma amino acids were affected.
Effects of arsenic deprivation in hamsters.
- BiologyMagnesium and trace elements
- 1990
The findings indicate that the hamster is a suitable animal for arsenic deprivation studies and support the hypothesis that arsenic may have a physiological role that influences methionine/methyl metabolism.
Role of polyamines and their antimetabolites in clinical medicine.
- BiologySpecial topics in endocrinology and metabolism
- 1983
The role of polyamines in clinical medicine is coming of age, and it is almost certain that polyamine antimetabolites will soon find their place among the drug regimens used for the treatment of human malignancies and, possibly, also of hyperproliferative skin diseases.
Heat shock gene expression and cytoskeletal alterations in mouse neuroblastoma cells.
- BiologyExperimental cell research
- 1987
Further characterization of the posttranslational modifications of core histones in response to heat and arsenite stress in Drosophila.
- BiologyBiochemistry and cell biology = Biochimie et biologie cellulaire
- 1986
Investigation in Drosophila cultured cells found changes in the patterns of core histone methylation and acetylation may be correlated with the reorganization of gene activity brought about by the heat shock.