Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.

@article{Wentworth2002EvidenceFA,
  title={Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation.},
  author={Paul Wentworth and Jonathan E. McDunn and Anita D. Wentworth and Cindy Takeuchi and Jorge J Nieva and Teresa M. Jones and Cristina Bautista and Julie M Ruedi and Abel Guti{\'e}rrez and Kim D Janda and Bernard M. Babior and Albert Eschenmoser and Richard A Lerner},
  journal={Science},
  year={2002},
  volume={298 5601},
  pages={
          2195-9
        }
}
Recently, we showed that antibodies catalyze the generation of hydrogen peroxide (H2O2) from singlet molecular oxygen (1O2*) and water. Here, we show that this process can lead to efficient killing of bacteria, regardless of the antigen specificity of the antibody. H2O2 production by antibodies alone was found to be not sufficient for bacterial killing. Our studies suggested that the antibody-catalyzed water-oxidation pathway produced an additional molecular species with a chemical signature… CONTINUE READING

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