Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.

@article{Ferreira2009EvidenceFA,
  title={Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.},
  author={Anderson Jos{\'e} Ferreira and Vinayak Shenoy and Yoriko Yamazato and Srinivas Sriramula and Joseph Francis and Lihui Yuan and Ronald K Castellano and David A. Ostrov and Suk Paul Oh and Michael J. Katovich and Mohan K. Raizada},
  journal={American journal of respiratory and critical care medicine},
  year={2009},
  volume={179 11},
  pages={1048-54}
}
RATIONALE It has been proposed that an activated renin angiotensin system (RAS) causes an imbalance between the vasoconstrictive and vasodilator mechanisms involving the pulmonary circulation leading to the development of pulmonary hypertension (PH). Recent studies have indicated that angiotensin-converting enzyme 2 (ACE2), a member of the vasoprotective axis of the RAS, plays a regulatory role in lung pathophysiology, including pulmonary fibrosis and acute lung disease. Based on these… CONTINUE READING
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