Evidence for and Against Genetic Predispositions to Acute and Chronic Altitude Illnesses.

  title={Evidence for and Against Genetic Predispositions to Acute and Chronic Altitude Illnesses.},
  author={Martin J. MacInnis and Michael Stephen Koehle},
  journal={High altitude medicine \& biology},
  volume={17 4},
MacInnis, Martin J., and Michael S. Koehle. Evidence for and against genetic predispositions to acute and chronic altitude illnesses. High Alt Med Biol. 17:281-293, 2016.-Humans exhibit marked variation in their responses to hypoxia, with susceptibility to acute and chronic altitude illnesses being a prominent and medically important example. Many have hypothesized that genetic differences are the cause of these variable responses to hypoxia; however, until recently, these hypotheses were based… 

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Evidence for a genetic basis for altitude-related illness.

The epidemiological evidence for a genetic component to the various forms of altitude-related illness, such as innate susceptibility, familial clustering, and patterns of population susceptibility, as well as the molecular evidence for specific genetic risk factors are reviewed.

Evidence for a genetic basis for altitude illness: 2010 update.

Although numerous studies have been performed to investigate specific genes, few have looked for evidence of heritability or familial transmission, or for epidemiological patterns that would be consistent with genetically influenced conditions, and this article updates that review and attempts to tabulate all the available genetic data pertaining to these conditions.

The Genetics of Altitude Tolerance: The Evidence for Inherited Susceptibility to Acute Mountain Sickness

The data suggest that genotype contributes to capacity to rapidly and efficiently acclimatize to altitude; nevertheless, the mechanisms by which this occurs have yet to be elucidated.

Genetic association analysis of chronic mountain sickness in an Andean high-altitude population.

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eNOS allelic variants at the same locus associate with HAPE and adaptation

The hypothesise that allelic variants at the same locus in a gene are involved in adaptation and HAPE and investigated the Glu298Asp and 4b/4a polymorphisms of the endothelial nitric oxide synthase gene and −344T/C, intron-2 conversion and Lys173Arg polymorphisms in 59 patients with HAPE.

Whole-genome sequencing uncovers the genetic basis of chronic mountain sickness in Andean highlanders.

Human genetic adaptation to high altitude.

  • L. Moore
  • Biology
    High altitude medicine & biology
  • 2001
Recent studies which address the question as to whether genetic adaptation to high altitude has occurred and suggest that Tibetans are better adapted are reviewed.

No association between alleles of the bradykinin receptor-B2 gene and acute mountain sickness

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Physiological risk factors for severe high-altitude illness: a prospective cohort study.

In a large population of altitude visitors, chemosensitivity parameters (high desaturation and low ventilatory response to hypoxia at exercise) were independent predictors of severe high-altitude illness and improved the discrimination ability of a risk prediction model.

Polymorphisms of Hypoxia-Related Genes in Subjects Susceptible to Acute Mountain Sickness

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