Evidence for an unusual distribution of chlorphentermine in vivo

  title={Evidence for an unusual distribution of chlorphentermine in vivo},
  author={Karl Seiler and Otmar Wassermann},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
3H-Chlorphentermine is selectively taken up by secreting tissues, the reticulo-endothelial and lymphatic system and other lipid-rich organs, like central nervous system, retina and lungs. Considerable amounts are still present at least 1 week after a single i.v. injection. The extensive binding of chlorphentermine in these lipid-or phospholipid-rich organs is probably due to strong complex formation between this drug and phospholipids. Comparison of this distribution pattern with that of other… CONTINUE READING

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