Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension.

@article{New1977EvidenceFA,
  title={Evidence for an unidentified steroid in a child with apparent mineralocorticoid hypertension.},
  author={Maria I. New and Lenore S. Levine and Edward G. Biglieri and J A Pareira and Stanley Ulick},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1977},
  volume={44 5},
  pages={924-33}
}
A unique syndrome in a three-year-old American Indian girl was characterized by signs and symptoms of mineralocorticoid excess in the absence of excessive secretion of any known sodium-retaining steroids. Hypertension and hypokalemic alkalosis were corrected by spironolactone or a low sodium diet. Plasma renin activity was suppressed but the secretion of aldosterone was undetectable and was not stimulated by salt depletion. There was no evidence of abnormal accumulation of aldosterone… CONTINUE READING

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