Evidence for an opiomelanotropin acetyltransferase in the rat pituitary neurointermediate lobe

@article{Chappell1982EvidenceFA,
  title={Evidence for an opiomelanotropin acetyltransferase in the rat pituitary neurointermediate lobe},
  author={M. Chappell and Y. P. Loh and T. O'donohue},
  journal={Peptides},
  year={1982},
  volume={3},
  pages={405-410}
}
  • M. Chappell, Y. P. Loh, T. O'donohue
  • Published 1982
  • Biology, Medicine
  • Peptides
  • Results of this study demonstrate two distinct forms of acetyltransferase activity which will acetylate alpha-MSH. These acetyltransferases are distinguished by pH optima, subcellular distribution and sensitivity to magnesium and several solubilizing detergents. A general acetyltransferase, as characterized in the rat pituitary anterior lobe and lens, has a pH optima of 7.4 and is inhibited by magnesium. Subcellular fractionation of anterior and neurointermediate lobes revealed that this… CONTINUE READING
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