Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats

@article{Lane2005EvidenceFA,
  title={Evidence for an intrinsic mechanism of antinociceptive tolerance within the ventrolateral periaqueductal gray of rats},
  author={Diane A. Lane and Parimal A. Patel and Michael M. Morgan},
  journal={Neuroscience},
  year={2005},
  volume={135},
  pages={227-234}
}
  • Diane A. Lane, Parimal A. Patel, Michael M. Morgan
  • Published in Neuroscience 2005
  • Medicine, Biology
  • Repeated microinjections of morphine into the ventrolateral periaqueductal gray produce antinociceptive tolerance. This tolerance may be a direct effect of morphine on cells within the ventrolateral periaqueductal gray or may require activation of downstream structures such as the rostral ventromedial medulla or spinal cord. Experiment 1 examined whether tolerance develops when opioid receptors in the ventrolateral periaqueductal gray are blocked prior to repeated systemic morphine… CONTINUE READING

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