Evidence for an insulin-like growth factor autocrine-paracrine system in the retinal photoreceptor-pigment epithelial cell complex.

@article{Waldbillig1991EvidenceFA,
  title={Evidence for an insulin-like growth factor autocrine-paracrine system in the retinal photoreceptor-pigment epithelial cell complex.},
  author={R J Waldbillig and Bruce A. Pfeffer and Timothy J Schoen and Andy Adler and Zila Shen-Orr and Louis M. Scavo and Derek Leroith and Gerald J. Chader},
  journal={Journal of neurochemistry},
  year={1991},
  volume={57 5},
  pages={1522-33}
}
The interphotoreceptor matrix (IPM), lying between retinal photoreceptor and pigment epithelial (RPE) cells, contains insulin-like growth factor I (IGF-I) immunoreactivity that co-elutes with authentic human IGF-I in HPLC analyses. Cultured human RPE cells synthesize and release IGF-I, raising the possibility that the RPE serves as a source of IPM IGF-I in vivo. Photoreceptor rod outer segments and cultured monkey RPE cells express specific IGF-I receptors with alpha-subunits of 120 and 138 kDa… CONTINUE READING

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