Evidence for an extrakaryotic mutation affecting the maintenance of the rho factor in yeast.

@article{Handwerker1973EvidenceFA,
  title={Evidence for an extrakaryotic mutation affecting the maintenance of the rho factor in yeast.},
  author={A Handwerker and Rudolf J. Schweyen and Klaus Wolf and Fritz Kaudewitz},
  journal={Journal of bacteriology},
  year={1973},
  volume={113 3},
  pages={1307-10}
}
A newly isolated, temperature-sensitive mutant of a haploid strain of Saccharomyces cerevisiae is described. Its shift to nonpermissive temperature (35 C) resulted in an irreversible change to rho(-), causing, within four to six generations, more than 90% of the cells to form petite colonies. Genetic analysis revealed extrakaryotic inheritance of this temperature-sensitive mutation. Data presented indicate mutation of a gene in the mitochondrial deoxyribonucleic acid affecting the maintenance… CONTINUE READING