Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.

@article{Heine2008EvidenceFA,
  title={Evidence for an evolutionary conserved role of homothorax/Meis1/2 during vertebrate retina development.},
  author={Peer Heine and Eva Dohle and Keely M Bumsted-O'Brien and Dieter Engelkamp and Dorothea Schulte},
  journal={Development},
  year={2008},
  volume={135 5},
  pages={805-11}
}
During eye development in D. melanogaster, the TALE-homeodomain protein Homothorax (Hth) is expressed by progenitor cells ahead of the neurogenic wave front, promotes rapid proliferation of these cells and is downregulated before cells exit the cell cycle and differentiate. Here, we present evidence that hth function is partially conserved in vertebrates. Retinal progenitor cells (RPCs) in chicks and mice express two Hth-related proteins, Meis1 and Meis2 (Mrg1), in species-specific temporal… CONTINUE READING