• Biology, Medicine
  • Published in
    Journal of the American…
    1999

Evidence for an essential role of megalin in transepithelial transport of retinol.

@article{Christensen1999EvidenceFA,
  title={Evidence for an essential role of megalin in transepithelial transport of retinol.},
  author={Erik Ils{\o} Christensen and J O Moskaug and Henrik Vorum and Christian Jacobsen and Thomas Erik Gundersen and Anders Nykjaer and Rune Blomhoff and Thomas E. Willnow and S{\o}ren Kragh Moestrup},
  journal={Journal of the American Society of Nephrology : JASN},
  year={1999},
  volume={10 4},
  pages={
          685-95
        }
}
Transepithelial transport of retinol is linked to retinol-binding protein (RBP), which is taken up and also synthesized in a number of epithelia. By immunocytochemistry of human, rat, and mouse renal proximal tubules, a strong staining in apical endocytic vacuoles, lysosomes, endoplasmic reticulum, Golgi, and basal vesicles was observed, in accordance with luminal endocytic uptake as well as a constitutive synthesis and basal secretion of RBP. Analysis of mice with target disruption of the gene… CONTINUE READING

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