Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA.

@article{Papenfort2010EvidenceFA,
  title={Evidence for an autonomous 5' target recognition domain in an Hfq-associated small RNA.},
  author={Kai Papenfort and Marie Bouvier and Franziska Mika and Cynthia M. Sharma and J{\"o}rg Vogel},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 47},
  pages={20435-40}
}
The abundant class of bacterial Hfq-associated small regulatory RNAs (sRNAs) parallels animal microRNAs in their ability to control multiple genes at the posttranscriptional level by short and imperfect base pairing. In contrast to the universal length and seed pairing mechanism of microRNAs, the sRNAs are heterogeneous in size and structure, and how they regulate multiple targets is not well understood. This paper provides evidence that a 5' located sRNA domain is a critical element for the… CONTINUE READING

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