Evidence for an apical sorting signal on the ectodomain of human aminopeptidase N.

@article{Vogel1992EvidenceFA,
  title={Evidence for an apical sorting signal on the ectodomain of human aminopeptidase N.},
  author={Lotte Katrine Vogel and Martin Spiess and Hans Sj{\"o}str{\"o}m and Ove B Nor{\'e}n},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 4},
  pages={2794-7}
}
In polarized epithelial cells aminopeptidase N is targeted to the apical membrane. The aim of this study was to determine whether a sorting signal is necessary for its correct transport to the apical membrane and, if so, to localize this sorting signal to one of the domains of the transmembrane protein. Anchor-minus aminopeptidase N, consisting of the hemagglutinin signal peptide including its cleavage site, and the ectoplasmic domain of human aminopeptidase N were stably expressed in Madin… CONTINUE READING

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