Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).

@article{MynettJohnson1998EvidenceFA,
  title={Evidence for an allelic association between bipolar disorder and a Na+, K+ adenosine triphosphatase alpha subunit gene (ATP1A3).},
  author={Lesley Mynett-Johnson and Vince Murphy and J Mccormack and Denis C. Shields and Elizabeth Claffey and Paul E. Manley and Patrick McKeon},
  journal={Biological psychiatry},
  year={1998},
  volume={44 1},
  pages={47-51}
}
BACKGROUND Disturbances in central nervous system Na+, K+ adenosine triphosphatase (ATPase) activity have previously been proposed as being involved in the pathophysiology of bipolar mood disorder. METHODS We have examined one particular alpha subunit of this enzyme for allelic association in a sample of 85 Irish bipolar patients and 85 matched controls. RESULTS There was evidence for an overall allelic association between the disease and a dinucleotide polymorphism within the ATP1A3 gene… CONTINUE READING

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