Evidence for an S-phase checkpoint regulating DNA replication after heat shock: a review.

@article{Iliakis2004EvidenceFA,
  title={Evidence for an S-phase checkpoint regulating DNA replication after heat shock: a review.},
  author={George Iliakis and Thomas Krieg and Jun Jie Guan and Yu-na Wang and Deenis Leeper},
  journal={International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group},
  year={2004},
  volume={20 2},
  pages={
          240-9
        }
}
Exposure of cells to heat inhibits a number of nuclear activities associated with semi-conservative replication of DNA including the incorporation of radiolabelled precursors into acid-insoluble DNA, the initiation of new replicons, the elongation of the DNA fibre at the replication fork, the synthesis and deposition of new histones into chromatin and the reorganization of nascent DNA into mature chromatin. These effects are likely to underlie the heat sensitivity of S-phase cells and may… CONTINUE READING
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