Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

@article{Harfe2004EvidenceFA,
  title={Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities},
  author={Brian D Harfe and Paul J. Scherz and Sahar Nissim and Hua Tian and Andrew P. McMahon and Clifford J Tabin},
  journal={Cell},
  year={2004},
  volume={118},
  pages={517-528}
}
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis. This activity has been modeled as a concentration-dependent response to a diffusible morphogen. Using recombinase base mapping in the mouse, we determine the ultimate fate of the Shh-producing cells. Strikingly, the descendants of the Shh-producing cells encompass all cells in the two most posterior… CONTINUE READING
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Showing 1-10 of 23 references

Fate map of mouse and Desert hedgehog

  • Q. Guo, C. Loomis, A. L. Joyner
  • Mech . Dev .
  • 2003
1 Excerpt

acid to the anterior margin of the developing chick limb

  • D. P. Leone, S. Genoud, +7 authors U. Suter
  • J . Embryol . Tamoxifen - inducible glia…
  • 2003

to specify additional digits in the developing chick wing . Nature Shh and Gli 3 are dispensable for limb skeleton formation but regu - 289 , 295 – 298 . late digit number and identity

  • C. Tickle, Y. Litingtung, R. D. Dahn, Y. Li, J. F. Fallon, C. Chiang
  • Nature
  • 2002

, and Williams , K . P . Hedgehog

  • L. V. Goodrich, R. L. Johnson, +8 authors R. Blake Pepinsky
  • Genes Dev .
  • 2001

Cholesterol modification lished online July 21 , 2004 . PMID : 15269168 of sonic hedgehog is required for long - range signaling activity and effective modulation of signaling by Pct 1

  • H. Tian, T. Tenzen, +5 authors B. Pub-St-Jacques
  • 2001

Some distal esis

  • D. Fraidenraich, C. A. Loomis
  • Major Problems in Developmental Biology ,
  • 2001

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