Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

@article{Harfe2004EvidenceFA,
  title={Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities},
  author={B. Harfe and P. Scherz and S. Nissim and H. Tian and A. McMahon and C. Tabin},
  journal={Cell},
  year={2004},
  volume={118},
  pages={517-528}
}
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis. This activity has been modeled as a concentration-dependent response to a diffusible morphogen. Using recombinase base mapping in the mouse, we determine the ultimate fate of the Shh-producing cells. Strikingly, the descendants of the Shh-producing cells encompass all cells in the two most posterior… Expand
876 Citations
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