Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities

  title={Evidence for an Expansion-Based Temporal Shh Gradient in Specifying Vertebrate Digit Identities},
  author={Brian D Harfe and Paul J. Scherz and Sahar Nissim and Hua Tian and Andrew P. McMahon and Clifford J Tabin},
The zone of polarizing activity (ZPA) in the posterior limb bud produces Sonic Hedgehog (Shh) protein, which plays a critical role in establishing distinct fates along the anterior-posterior axis. This activity has been modeled as a concentration-dependent response to a diffusible morphogen. Using recombinase base mapping in the mouse, we determine the ultimate fate of the Shh-producing cells. Strikingly, the descendants of the Shh-producing cells encompass all cells in the two most posterior… CONTINUE READING
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