Evidence for an A2-subtype adenosine receptor on pancreatic glucagon secreting cells.

@article{Chapal1985EvidenceFA,
  title={Evidence for an A2-subtype adenosine receptor on pancreatic glucagon secreting cells.},
  author={Jeannie Chapal and Marie-Madeleine Loubati{\`e}res-Mariani and Pierre Petit and Marcia E. Roye},
  journal={British journal of pharmacology},
  year={1985},
  volume={86 3},
  pages={565-9}
}
The effects of a 5'-substituted analogue of adenosine, 5'-N-ethylcarboxamidoadenosine (NECA) have been studied on glucagon secretion in vitro, using the isolated pancreas of the rat perfused in the presence of glucose (2.8 mM). NECA provoked a peak of glucagon secretion, the kinetics of which were comparable to those previously obtained with adenosine. The effect was concentration-dependent and appeared at nanomolar concentrations. The EC50 was approximately 4 X 10(-8) M. A comparison of… CONTINUE READING

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