Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice

@article{Reinke2018EvidenceFA,
  title={Evidence for altered osteoclastogenesis in splenocyte cultures from VDR knockout mice},
  author={Daniel Reinke and Yolandi Starczak and Masakazu Kogawa and Kate R. Barratt and Gerald J Atkins},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2018},
  volume={177},
  pages={96-102}
}
The indirect action of 1α,25(OH)2-vitamin-D3 (1,25D) on the osteoclast through stromal signalling is well established. The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. We showed previously that local 1,25D synthesis in osteoclasts modified osteoclastogenesis and osteoclastic resorptive activity. In this study, we hypothesised that osteoclasts lacking VDR expression would display an enhanced resorptive capacity due to the loss of 1,25D signalling… CONTINUE READING
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