Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex.

@article{Philpot2003EvidenceFA,
  title={Evidence for altered NMDA receptor function as a basis for metaplasticity in visual cortex.},
  author={Benjamin D Philpot and Juan Sebasti{\'a}n Espinosa and Mark F. Bear},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 13},
  pages={5583-8}
}
Sensory deprivation alters the properties of synaptic plasticity induced in the superficial layers of the visual cortex, facilitating long-term potentiation and reducing long-term depression (LTD) across a range of stimulation frequencies. Available data are compatible with either a downregulation of the mechanisms of LTD or an upregulation of NMDA receptor function in the visual cortex of dark-reared animals. Here, we provide evidence for enhanced NMDA receptor function by showing that… CONTINUE READING

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