Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats.

@article{Baumann1995EvidenceFA,
  title={Evidence for alterations in presynaptic serotonergic function during withdrawal from chronic cocaine in rats.},
  author={Michael Heinrich Baumann and K M Becketts and Richard B. Rothman},
  journal={European journal of pharmacology},
  year={1995},
  volume={282 1-3},
  pages={87-93}
}
The effects of repeated cocaine administration on serotonin (5-hydroxytryptamine, 5-HT) function were investigated by comparing the corticosterone response to 5-HT receptor agonists in cocaine-treated and vehicle-treated rats. Male rats were fitted with indwelling jugular catheters and received cocaine (15 mg/kg i.p., b.i.d.) or saline for 7 days. Rats were challenged with either saline, the 5-HT releaser fenfluramine (1.2 mg/kg i.v.), the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino… CONTINUE READING