Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.

@article{Baumann2004EvidenceFA,
  title={Evidence for alterations in alpha2-adrenergic receptor sensitivity in rats exposed to repeated cocaine administration.},
  author={Michael Heinrich Baumann and Allison B Milchanowski and Richard B. Rothman},
  journal={Neuroscience},
  year={2004},
  volume={125 3},
  pages={683-90}
}
It is well established that cocaine stimulates monoamine transmission by blocking reuptake of norepinephrine (NE), dopamine and serotonin into nerve cells, yet few investigations have addressed the effects of chronic cocaine on NE function. In the present study, we examined the effects of repeated cocaine injections on neuroendocrine responses evoked by the alpha2-adrenergic receptor agonist, clonidine. Previous findings show that clonidine increases pituitary growth hormone (GH) secretion by a… CONTINUE READING
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