Evidence for adrenergic mediation of cholinergic inhibition of prolactin release.

@article{Grandison1976EvidenceFA,
  title={Evidence for adrenergic mediation of cholinergic inhibition of prolactin release.},
  author={Lindsey Grandison and Joseph Meites},
  journal={Endocrinology},
  year={1976},
  volume={99 3},
  pages={775-9}
}
Pilocarpine, a cholinergic agonist, significantly reduced the high levels of serum prolactin in estrogen-primed male rats and in female rats on the late afternoon of proestrus. In male rats treated with reserpine, chlorpromazine, haloperidol, or pimozide, serum prolactin levels were greatly elevated. Subsequent treatment with pilocarpine failed to reduce serum prolactin concentrations in these rats. When atropine, a cholinergic antagonist, was injected ip in doses of 3 to 250 mg/kg into male… CONTINUE READING