Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception.

@article{Tyler1998EvidenceFA,
  title={Evidence for additional neurotensin receptor subtypes: neurotensin analogs that distinguish between neurotensin-mediated hypothermia and antinociception.},
  author={Berry M Tyler and Bernadette Cusack and Christopher L. Douglas and Terrance M Souder and Elliott Richelson},
  journal={Brain research},
  year={1998},
  volume={792 2},
  pages={246-52}
}
Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of additional NTR subtypes. We have identified a NT analog of the NT(8-13) fragment, NT27, that selectively causes only the hypothermic response in vivo, when microinjected into the… CONTINUE READING

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