Evidence for activity-regulated hormone-binding cooperativity across glycoprotein hormone receptor homomers.

Abstract

Glycoprotein hormone receptors show strong negative cooperativity. As a consequence, at physiological hormone concentrations, a single agonist binds to a receptor dimer. Here we present evidence that constitutively active receptors lose cooperative allosteric regulation in direct relation with their basal activity. The most constitutive mutants lost nearly… (More)
DOI: 10.1038/ncomms1991

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