Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.

@article{Miller2010EvidenceFA,
  title={Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.},
  author={Jordan D. Miller and Robert M. Weiss and Kristine M Serrano and Lauren E Castaneda and Robert M. Brooks and Kathy Zimmerman and Donald D. Heistad},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2010},
  volume={30 12},
  pages={2482-6}
}
OBJECTIVE To test the hypothesis that valvular calcium deposition, pro-osteogenic signaling, and function can be altered in mice with advanced aortic valve disease. METHODS AND RESULTS "Reversa" mice were given a Western-type diet for 12 months and screened for the presence of aortic valve stenosis. Mice with advanced valve disease were assigned to 1 of 2 groups: (1) those with continued progression for 2 months and (2) those with regression for 2 months, in which lipid lowering was… CONTINUE READING