Evidence for activation of the central nervous system-pituitary mechanism for gonadotropin secretion at the time of puberty in the male rat.

@article{Matsumoto1986EvidenceFA,
  title={Evidence for activation of the central nervous system-pituitary mechanism for gonadotropin secretion at the time of puberty in the male rat.},
  author={Alvin M. Matsumoto and A E Karpas and Maurice Southworth and Daniel M. Dorsa and William J. Bremner},
  journal={Endocrinology},
  year={1986},
  volume={119 1},
  pages={362-9}
}
During sexual development in the male rat, serum testosterone (T) levels increase markedly at 45-60 days of age. At the time of the pubertal rise in T levels, activation of the hypothalamic-pituitary axis is difficult to demonstrate, since there is little change in serum LH levels and a decrease in serum FSH levels. We determined whether experimental maintenance of stable pubertal T levels in these animals as they passed through the normal age of puberty would allow demonstration of a major… CONTINUE READING