Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat.

@article{Westerink2002EvidenceFA,
  title={Evidence for activation of histamine H3 autoreceptors during handling stress in the prefrontal cortex of the rat.},
  author={Ben H. C. Westerink and Thomas I. H. F. Cremers and Jan B de Vries and Hans Liefers and Nan Tran and Peter de Boer},
  journal={Synapse},
  year={2002},
  volume={43 4},
  pages={238-43}
}
On-line microdialysis of histamine in 10-min samples of the prefrontal cortex of the conscious rat is described. The HPLC-fluorescent assay for histamine in dialysates has been significantly simplified by using only one postcolumn reagent line instead of the three reagent lines described in earlier methods. The method is selective, sensitive (detection limit: 2-3 fmol on column), and linear over a large concentration range. Basal values of histamine decreased to about 50% of basal levels during… CONTINUE READING

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