Evidence for abrogation of oncogene-induced radioresistance of mammary cancer cells by hexadecylphosphocholine in vitro.

@article{Bruyneel1993EvidenceFA,
  title={Evidence for abrogation of oncogene-induced radioresistance of mammary cancer cells by hexadecylphosphocholine in vitro.},
  author={Erik A. Bruyneel and Guy Storme and Denis C. C. Schallier and Dirk L Van den Berge and Peter Hilgard and Marc M. K. Mareel},
  journal={European journal of cancer},
  year={1993},
  volume={29A 14},
  pages={1958-63}
}
Hexadecylphosphocholine (HePC), an experimental and clinical antitumour agent of the alkyllysophospholipid group, was tested for its radiosensitising effect on a panel of nine human mammary cancer cell lines in vitro. Growth inhibition by ionising radiation and recovery from it were not influenced by pretreatment with HePC in most cases, except for two cell lines expressing an activated ras oncogene. In the latter we found an enhanced radioresistance that was abolished by pretreatment with HePC… CONTINUE READING

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