Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.

@article{Klitgaard1998EvidenceFA,
  title={Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy.},
  author={Henrik V Klitgaard and Alain C Matagne and J M Gobert and Ernst W{\"u}lfert},
  journal={European journal of pharmacology},
  year={1998},
  volume={353 2-3},
  pages={191-206}
}
The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of seizures and epilepsy were compared with the profile of several currently prescribed and newly developed antiepileptic drugs. Levetiracetam was devoid of anticonvulsant activity in the acute maximal electroshock seizure test and in the maximal pentylenetetrazol seizure test in mice (up to 540 mg/kg, i.p.) but exhibited potent protection against generalised epileptic… CONTINUE READING
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