Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.

@article{Sanggaard2006EvidenceFA,
  title={Evidence for a two-step mechanism involved in the formation of covalent HC x TSG-6 complexes.},
  author={Kristian Wejse Sanggaard and Carsten S Sonne-Schmidt and Christian Jacobsen and Ida Bukh Th\ogersen and Zuzana Valnickova and H G Wisniewski and Jan J Enghild},
  journal={Biochemistry},
  year={2006},
  volume={45 24},
  pages={7661-8}
}
IalphaI and TSG-6 interact to form a covalent bond between the C-terminal Asp alpha-carbon of an IalphaI heavy chain (HC) and an unknown component of TSG-6. This event disrupts the protein-glycosaminoglycan-protein (PGP) cross-link and dissociates IalphaI. In simple terms the interaction involves 5 components: (i) the IalphaI HCs, (ii) bikunin, (iii) chondroitin sulfate chain, (iv) TSG-6, and (v) divalent cations. To understand the molecular mechanism of complex formation, the effect of these… CONTINUE READING

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