Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.

@article{Yu2013EvidenceFA,
  title={Evidence for a tumor suppressor role for the large tumor suppressor genes LATS1 and LATS2 in human cancer.},
  author={Tian Yu and John C. Bachman and Zhi-chun Lai},
  journal={Genetics},
  year={2013},
  volume={195 3},
  pages={
          1193-6
        }
}
The role of Large tumor suppressor LATS/Warts in human cancer is not clearly understood. Here we show that hLATS1/2 cancer mutations affect their expression and kinase activity. hLATS1/2 mutants exhibit a decreased activity in inhibiting YAP and tissue growth. Therefore, hLATS1/2 alleles from human cancer can be loss-of-function mutations. 
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Information in database on SNP ’ s found in the same amino acid position

  • P. C. NG
  • The PolyPhen2 program The SNAP program
  • 2003

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